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Addressing the critical need for cancer-selective targets

A scarcity of novel cancer-selective targets limits effective treatment options for most patients. Current targets are generally found in small patient populations, and are also present on healthy tissue, leading to target-mediated dose limiting toxicities.

PairX unleashes the clinical impact of selective biologics

Our biology-driven, variant-specific approach reveals a new class of therapeutic targets to yield highly selective drugs that better discriminate between tumor and normal tissue for improved efficacy and best-in-class tolerability.

Novel biology-based cancer targets Paired with optimal therapeutic modalities to revolutionize cancer-selective biologics

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PairX is pioneering the development of next-generation cancer-selective biologics by identifying novel, highly prevalent, tumor-selective cell surface variants. Founded on IP exclusively licensed from Duke-NUS Medical School, Singapore, we are advancing a robust pipeline of potential first- and best-in-class tumor-selective therapies targeting prevalent cancers in substantial patient populations.

Designing cancer-selective therapeutics

Novel selective targets have meaningful therapeutic windows, limit off-target effects, and often play a functional role in carcinogenesis

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Targeting large proportions of patient populations

Substantial proportions of cancer patient populations harbor these variants, ensuring benefit to broader patient populations

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Selecting highly actionable drug targets

Variants represent highly actionable drug targets paired with the optimal therapeutic modality

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Unlocking the ability to select the most effective
therapeutic modality
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T-cell engagers (TCEs)

Antibody-drug conjugates (ADCs)

Radioligands

Bispecifics

Others

Variant-selective biologics offer broad treatment opportunities

Our approach offers hope to a wider range of patients living with difficult-to-treat cancers and is poised for outsized impact in areas of unmet need.

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We see the opportunity for therapeutic impact in larger populations than those with specific oncogenic mutations.

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And we're just getting started.

Investors

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